Regulatory components in Citrobacter freundii ampC beta-lactamase induction.
نویسندگان
چکیده
منابع مشابه
Identification of ACT-1 Plasmid-Mediated AmpC β-Lactamase Producing Citrobacter freundii from a Chinese Patient
Dear Sir, Enterobacteriaceae, other than Escherichia spp. and Klebsiella spp., can cause serious nosocomial infections and appear to have become increasingly drug resistant. Citrobacter freundii, belonging to the Enterobacteriaceae family, is a prominent opportunistic pathogen responsible for serious infections in immunocompromised individuals. C. freundii is characterized by the presence of ch...
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To determine whether the widespread clinical use of -lactams has been selective for Citrobacter freundiiderived alleles of plasmid ampC genes, we generated a Bayesian consensus phylogeny of the published ampC sequences and compared the MICs of 16 -lactam antibiotics for Escherichia coli strains containing cloned copies of the C. freundii ampC alleles. We found that for the majority of compounds...
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In competition assays for radiolabeled penicillin, penicillin-binding proteins (PBPs) 4, 7a, and 7b showed very high affinities for strong inducers of AmpC beta-lactamase. Loss of PBP 4 resulted in diminished inducibility. This suggests that if PBPs are involved in induction of AmpC beta-lactamase, there is probably a redundancy in function among the different PBPs.
متن کاملPrediction of two- and three-amino-acid sequences of Citrobacter Freundii beta-lactamase from its amino acid composition.
The repeated amino-acid sequences in Citrobacter Freundii beta-lactamase may be indispensable for its function, because such repetitions cannot be simply attributed to a chance. In order to fully explore the functional units in Citrobacter Freundii beta-lactamase, it may need to analyse all the amino acid pairs, triplets, etc. along Citrobacter Freundii beta-lactamase from one terminal to the o...
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Dear Sir, Carbapenems are one of the most critically important antimicrobials and are considered as last-choice drugs in clinical settings. However, the emergence and dissemination of Enterobacteriaceae carrying acquired metallo-β-lactamases (MBLs) is being increasingly reported throughout the world, presenting a serious threat to the effectiveness of carbapenem treatment [1]. Acquired MBLs, su...
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ژورنال
عنوان ژورنال: Proceedings of the National Academy of Sciences
سال: 1985
ISSN: 0027-8424,1091-6490
DOI: 10.1073/pnas.82.14.4620